A Massive List of Other Drugs in the Same Class as Gabapentin

Looking for other drugs in the same class as Gabapentin? We’ve compiled a large list of Gabapentin alternatives.

Gabapentin is classified as an anticonvulsant. It’s used for pain management, epilepsy, restless leg syndrome and hot flashes. In general, anticonvulsants “work” by increasing the inhibitory activity of the neurotransmitter GABA, or decrease the activity of the excitatory neurotransmitter glutamate.

Gabapentin is a GABA analogue – it’s chemical structure is a modified version of the neurotransmitter GABA. This means that Gabapentin behaves similarly to GABA in the brain. Gabapentin tends to decrease anxiety, pain perception and promote a relaxed mental state.

What Other Drugs Are in the Same Class as Gabapentin?

The follow table is a list of Gabapentin alternatives – all of which are anticonvulsants. Most of them are approved for epilepsy, but are used off-label for other purposes. For example, valproic acid is used both for epilepsy but also as a mood stabilizer.

AnticonvulsantMechanismComments
CarbamazepineVoltage-dependent sodium channelsTreats focal/generalized seizures, bipolar disorder, chronic pain (trigeminal neuralgia)
PhenytoinVoltage-dependent sodium channelsfocal/generalized seizures, status epilepticus, mixed seizures
LamotrigineVoltage-dependent sodium channelsfocal seizures and generalized seizures (adjunct), mood disorders
OxcarbazepineVoltage-dependent sodium channelsFocal and secondarily generalized tonic clonic seizures
ZonisamideVoltage-dependent sodium channels and T-type calcium channelsFocal and generalized seizures in adults and children
LacosamideEnhancement of slow inactivation of voltage-dependent sodium channelsFocal-onset seizures for adults
RufinamideProlongs inactivate state of sodium channelsSeizures associated with Lennox Gastaut syndrome (LGS)
EslicarbazepineBlockade of voltage-gated sodium channels in rapid firing neuronsFocal-onset seizures for adults
EthosuximideDiminishes T-type calcium currentsAbsence seizures
PhenobarbitalIncreases GABA(A) receptor activityGeneralized and focal seizures
TiagabineIncreases GABA levelsAdjunct for focal seizures
VigabatrinIrreversible inhibitor of GABA-transaminaseRefractory focal seizures
ClobazamBenzodiazepineAdjunct for >2 y/o patients with Lennox-Gastaut syndrome (LGS)
Clorazepate, diazepam, lorazepamBenzodiazepineMyoclonic and atonic seizures, focal and generalized tonic-clonic seizures
ClobazamBenzodiazepineAdjunct for >2 y/o patients with Lennox-Gastaut syndrome (LGS)
PerampanelAMPA-type glutamate receptor antagonistfocal-onset and primary generalized tonic-clonic seizures in patients >12
Valproateblocks voltage-dependent sodium channels, increases GABA levels, increases GABA synthesisgeneralized and focal seizures
FelbamateBlocks NMDA-type glutamate receptors and increases GABA functionFocal seizures and Lennox-Gastaut syndrome
TopiramateBlocks voltage-dependent sodium channels, enhances GABA activity, antagonizes NMDA-type glutamate receptorsAdjunct for focal seizures in adults and children >2
GabapentinBinds voltage-dependent calcium channelsAdjunct for refractory focal seizures
LeviracetamBinds synaptic vesicle protein SV2A, GABA modulationAdjunct for focal-onset seizures, myoclonic seizures, generalized tonic-clonic seizures with idiopathic generalized epilepsy
Pregabalinbinds voltage-gated calcium channels and affects glutamate, noradrenaline, and substance PAdjunct for focal seizures, neuropathic pain, postherpetic neuralgia, fibromyalgia
EzogabineOpens KCNQ2/3 voltage-gated potassium channelsAdjunct for focal seizures in adults
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