L-Tyrosine and Adderall: Read This Before Mixing Them

L-tyrosine and Adderall are somewhat related. L-tyrosine is a non-essential dietary amino acid and a precursor to dopamine and other catecholamines like norepinephrine.

L-tyrosine is "natural" in the sense that it’s an amino acid present in foods.

L-tyrosine is said to be non-essential because it can be synthesized from phenylalanine in the body by the simple addition of an OH group at the para position of the benzene ring. Adderall, by contrast, is a catecholamine-releasing agent; a potent prescription drug that promotes dopamine release to increase attention.

Mixing L-Tyrosine and Adderall

Mixing l-tyrosine and Adderall is not dangerous. You might think that it would be dangerous to mix the two because both substances increase synaptic dopamine levels in the brain. Increasing dopamine via multiple mechanisms can be dangerous, but l-tyrosine only very weakly and indirectly increases dopamine.

While it’s not dangerous to mix Adderall and l-tyrosine, you will get more mileage by avoiding mixing the two. It’s better instead to take l-tyrosine in the evening or even before bed, after Adderall has worn off. This works better because dopamine and other catecholamines (norepinephrine) will be depleted after Adderall use during the day. Since l-tyrosine is a dopamine precursor, taking it at night will theoretically replenish the dopamine depleted by daytime Adderall use.

How L-Tyrosine Affects The Brain

Once l-tyrosine penetrates the blood brain barrier, it is converted to L-DOPA by the enzyme tyrosine hydroxylase. This enzyme is the rate-limiting step in the synthesis of dopamine. In other words, tyrosine hydroxylase activity is the “bottleneck” that directly controls the rate at which dopamine is synthesized.

L-DOPA is the immediate precursor to dopamine and is used as a drug for the treatment of Parkinson’s disease.


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