Vyvanse Withdrawal - Dealing With The Comedown

Vyvanse withdrawal can be tough to cope with. Rest assured that with time, good nutrition and exercise you will beat Vyvanse withdrawal symptoms and recover 100%. If you plan to continue using Vyvanse, you may also want to take a look at this discussion about how to protect your brain from the potentially neurotoxic effects of amphetamines.

How Vyvanse Affects the Brain

Vyvanse is comprised of lisdexamfetamine, which is dextroamphetamine conjugated to the amino acid lysine. This formulation results in the gradual, more controlled (rather than instant) release of amphetamine.

Amphetamines are catecholamine releasing agents. That is, they promote the release of norepinephrine and dopamine in the synapse. Norepinephrine plays a role in the sympathetic (fight-or-flight) response to perceived danger or stress, and therefore can increase heart rate, blood pressure and affect other vital signs.

By enhancing catecholamine release, Vyvanse increases urgency and task salience, making it easier for patients with ADHD to concentrate.

Vyvanse Withdrawal Symptoms

The intensity and duration of Vyvanse withdrawal symptoms varies from person to person, and depends on the duration of your treatment with Vyvanse, dosage, and the condition of your overall health.

The symptoms of Vyvanse withdrawal are essentially identical to Adderall (mixed amphetamine salts) withdrawal, since the active agent in both Vyvanse and Adderall is the same–dextroamphetamine. (Though Adderall also contains levoamphetamine in addition to dextroamphetamine.)

You may experience increased hunger, fatigue, difficulty concentrating and low mood after discontinuing Vyvanse treatment.

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